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It kicks off at 20:45 CET (19:45 GMT) at the Stadio Olimpico in Rome.
It’s the last game of the Serie A round 28.
The Bianconcelesti are still without their best scorer, Valentin Castellanos, but have a big chance to leapfrog Juventus in fourth place after the Bianconeri’s 4-0 home loss to Atalanta on Sunday night.
The home side must cope without Luca Pellegrini, Elseid Hysaj, Valentin Castellanos and Nuno Tavares.
Isaak Touré and Razvan Sava are unavailable for the visitors.
Udinese are unbeaten in the last five matches, collecting four wins and just one draw.
Lazio beat Viktoria Plzen 2-1 in the first leg of the Europa League Round of 16 last week and will host the Czech side in the return leg this coming Thursday.
Football Italia will be following the game and the build-up live on the LIVEBLOG.
Great counterattack. Lucca wins the duel with Gila, and passes the ball to Thauvin inside the box. Provedel produces a double save; Lucca tries to score a bicycle kick attempt but finds the French striker again, who puts the ball inside an empty net.
Lazio 0-1 Udinese: Thauvin!
Udinese take the lead!
Tricky Thauvin shot from outside the box on the right, Provedel blocks it.
High Udinese press so Lazio find it hard to build from the back and create goal-scoring opportunities.
A dangerous cross from Lovric, Lucca doesn’t get at the end of it and Provedel makes the block.
Udinese clearance from the Zaccagni free kick.
Lazio push forward with Isaksen after a convincing Udinese start. Kamara commits a foul and gets a yellow card. Lazio free kick from the right-hand side of the box.
Kristensen’s foul on Zaccagni in Lazio’s defensive half. He’s already been warned. The next one will be a yellow.
We have kick-off. Udinese start the game.